The Urban League serves nearly 1,000 low-income families through the United Way of Greater St. Louis/Post Dispatch 100 Neediest Cases Programs. The majority of adopted families receive numerous boxes containing items such as bed linens, clothing, shoes, appliances, etc. Families also receive gift certfficates and financial aid.

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The 100 Neediest Cases began in 1922 as an annual charitable campaign that selects 100 families and individuals during November and December. The sponsoring organizations and other charities absorb the administrative cost. Local organizations adopt individual cases, donate food, medications, household necessities, holiday presents, etc.